Thousands are camped out at the de facto border with the UK in an attempt to illegally sneak into Britain, but French president Francois Hollande has declared it will bulldoze the entire site by the end of the year.
He has pledged to dismantle the sprawling slum city before winter, relocating the 9,000 inhabitants to 164 locations across France.
Work could begin as soon as October 17, Calais officials say.
But plans to shut down the camp and evenly distribute its inhabitants across the country has been met with fierce opposition from locals.
Residents of Pierrefeu and Forges-les-Bains took to the streets in outrage, with the mayor of Pierrefeu leading a march.
Mayor Patrick Martinelli led a procession of several hundred through the town on Saturday, objecting to government plans to house some migrants in the abandoned wing of a psychiatric hospital while their asylum applications are processed, or other options are considered.
Mr Martinelli said: “Even if we can understand the dismantling of Calais… our small towns are not the solution for this dismantling. We are too small to host so many people.”
Resident Laure Paul said: “I am ashamed because we repress the poorest. They need us, the people who are coming from abroad, and are dying in the seas.
Residents held signs saying ‘not against migrants, but against the state’ and ‘plan imposed from above (equals) mounting anger’.
He demanded a referendum on the issue, saying “All these people said to me ‘we must be consulted’.”
Pro-migrant rallies were also held in the towns over the weekend